Two-Component Signal Transduction as a Target for Microbial Anti-Infective Therapy
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چکیده
منابع مشابه
Two-component signal transduction as a target for microbial anti-infective therapy.
s of the 214th ACS National Meeting.20. Dong, J., S. Iuchi, H. S. Kwan, Z. Lu, and E. C. Lin. 1993. The deducedamino-acid sequence of the cloned cpxR gene suggests the protein is thecognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Gene 136:227–230.21. Dziejman, M., and J. J. Mekalanos. 1995. Two-component signal ...
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Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein. The histidine protein kinase, which is regulated by environmental stimuli, autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to an ...
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The bacterial communities in a wide range of environmental niches sense and respond to numerous external stimuli for their survival. Primarily, a source they require to follow up this communication is the two-component signal transduction system (TCS), which typically comprises a sensor Histidine kinase for receiving external input signals and a response regulator that conveys a proper change i...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1998
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.42.7.1529